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Taken together all patients with systemic lupus erythematosus have a mortality of approximately 1% per year. High-risk patients are at greater risk with a 20% 1-year, 35% 5-year and 45% 10-year mortality. Patients at high risk for lethal complications may be identified by renal disease, hypertension, lung involvement, anemia, thrombocytopenia, and antibodies to phospholipids, or active disease demonstrated by a high disease activity index score despite therapy.
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